GLP-1 receptor agonism
Semaglutide activates the GLP-1 receptor on pancreatic beta cells and in hypothalamic circuits studied for satiety signalling.
- Glucose-dependent insulin secretion
- Delayed gastric emptying
- Central appetite signalling
≥99% Purity
Semaglutide GLP-1
GLP-1 Receptor Studies
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PassedSterility & Endotoxins
PassedNet Content & Purity
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About this compound
Semaglutide is a long-acting GLP-1 receptor agonist with an albumin-binding fatty-acid side chain that extends its half-life to roughly one week. It is one of the most extensively published incretin analogues, with large randomised trials describing glycaemic control, weight trajectory, and cardiovascular endpoints.
Long-acting GLP-1 receptor agonist analogue
- Formula
- C187H291N45O59
- Molecular weight
- 4113.6 g/mol
- CAS / ID
- 910463-68-2
- Form
- Lyophilized powder
0%
Body-weight change
STEP-1, 68 weeks
0h
Plasma half-life
Published pharmacokinetic data
0+
Indexed studies
GLP-1 agonist literature
0
Amino acids
Acylated GLP-1 analogue
How It WorksReceptor biology Pharmacokinetics
How Semaglutide GLP-1 works
The pathways Semaglutide GLP-1 acts on — and what each one does. Signalling pathways studied in preclinical models · illustrative.
Extended half-life
C18 diacid conjugation and DPP-4 resistant substitutions produce a ~165-hour half-life in published pharmacokinetic work.
- Albumin binding
- DPP-4 resistance
- Weekly dosing interval in trials
Uses & applicationsMetabolic Glycaemic
What Semaglutide GLP-1 is researched for
The main areas Semaglutide GLP-1 is being studied for — and the study-reported figures behind them.
Weight-regulation research
STEP programme trials characterised body-weight change over 68 weeks in adults with obesity.
NEJM 2021
Type-2 diabetes models
SUSTAIN programme evaluated HbA1c response versus comparators.
Lancet 2017
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
- Body-weight change (68 wk)−14.9%
- HbA1c reductionReduced
- Appetite scoreReduced
Figures are representative of published research findings and shown for reference.
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Semaglutide GLP-1 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Compound Information
Full specification
| Compound | Semaglutide |
|---|---|
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.6 g/mol |
| CAS number | 910463-68-2 |
| Purity (HPLC) | ≥99% |
| Vial size | 10mg |
| Physical form | Lyophilized white powder |
| Storage | -20 °C, protected from light |
| Reconstitution | Bacteriostatic water |
| Intended use | Laboratory research only — not for human consumption |
FAQ
Common questions about Semaglutide GLP-1
Every Semaglutide lot is assayed by HPLC to ≥99% purity, with mass-spectrometry identity confirmation. The certificate of analysis for your lot is available in the COA library.
Store lyophilized vials at -20 °C protected from light. Once reconstituted with bacteriostatic water, keep refrigerated at 2–8 °C and use within the window described in your protocol.
No. This compound is supplied strictly as a reference material for in-vitro and laboratory research. It is not a drug, supplement, or food, and it is not intended for human or animal consumption.
Yes. Independent third-party laboratories run identity and purity panels on each production lot, and the signed report is archived by lot number.
Published Literature
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Zorva Lab claims.
For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
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