VPAC1 / VPAC2 signalling
VIP binds class-B GPCRs coupled to adenylate cyclase, raising intracellular cAMP in target tissues.
- cAMP / PKA cascade
- Smooth-muscle relaxation
- Neuro-immune crosstalk
≥99% Purity
VIP
Vasoactive Intestinal Peptide Studies
$195.00$146.25/vial with BOGO
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PassedSterility & Endotoxins
PassedNet Content & Purity
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About this compound
Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide of the secretin/glucagon superfamily. It signals through VPAC1 and VPAC2 receptors and has been studied for roles in vasodilation, circadian pacemaking in the suprachiasmatic nucleus, and immune modulation in inflammatory research models.
28-residue neuropeptide, VPAC1 / VPAC2 receptor ligand
- Formula
- C147H238N44O42S
- Molecular weight
- 3325.8 g/mol
- CAS / ID
- 37221-79-7
- Form
- Lyophilized powder
0
Amino acids
Native neuropeptide sequence
0
Receptor targets
VPAC1 and VPAC2
0+
Indexed studies
Neuro-immune and circadian research
0%
cAMP elevation
Reported in vitro signalling response
How It WorksReceptor biology Circadian biology
How VIP works
The pathways VIP acts on — and what each one does. Signalling pathways studied in preclinical models · illustrative.
Suprachiasmatic signalling
VIP-expressing neurons synchronise the central circadian pacemaker in published rodent work.
- SCN neuron coupling
- Phase-shift studies
- Sleep-wake research models
Uses & applicationsImmunology Vascular
What VIP is researched for
The main areas VIP is being studied for — and the study-reported figures behind them.
Inflammatory signalling
Studied for shifts in cytokine profile in autoimmune and sarcoidosis research models.
J Immunol
Vasodilation research
Examined for pulmonary and systemic vascular tone in preclinical models.
Am J Respir
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
- cAMP signalling (in vitro)Elevated
- Inflammatory markersReduced
- Vascular toneRelaxed
Figures are representative of published research findings and shown for reference.
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of VIP is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Compound Information
Full specification
| Compound | Vasoactive Intestinal Peptide (VIP) |
|---|---|
| Molecular formula | C147H238N44O42S |
| Molecular weight | 3325.8 g/mol |
| CAS number | 37221-79-7 |
| Purity (HPLC) | ≥99% |
| Vial size | 10mg |
| Physical form | Lyophilized white powder |
| Storage | -20 °C, protected from light |
| Reconstitution | Bacteriostatic water |
| Intended use | Laboratory research only — not for human consumption |
FAQ
Common questions about VIP
Every VIP lot is assayed by HPLC to ≥99% purity, with mass-spectrometry identity confirmation. The certificate of analysis for your lot is available in the COA library.
Store lyophilized vials at -20 °C protected from light. Once reconstituted with bacteriostatic water, keep refrigerated at 2–8 °C and use within the window described in your protocol.
No. This compound is supplied strictly as a reference material for in-vitro and laboratory research. It is not a drug, supplement, or food, and it is not intended for human or animal consumption.
Yes. Independent third-party laboratories run identity and purity panels on each production lot, and the signed report is archived by lot number.
Published Literature
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Zorva Lab claims.
For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
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