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99%+ HPLC purityThird-party testedCOA with every lotMass-spec confirmed identityISO/IEC 17025 labsEndotoxin screenedcGMP · US facilitySame-day dispatch · tracked
≥99% PuritySelank vial

Selank

Stress Response Studies

$65.00$48.75/vial with BOGO
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PassedSterility & Endotoxins
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Researchers also added
Bacteriostatic Water10mL
$13.00
Semax10mg
$90.00
About this compound

Selank is a peptide made of seven amino acids. It is based on tuftsin, a natural immune peptide. It carries the same stabilizing tail used in Semax, and both came out of the same Russian research institute. Studies in rodent models have measured GABA signaling, which is how the brain slows activity down, along with stress-related endpoints.

Synthetic tuftsin-derived heptapeptide

Formula
C33H57N11O8
Molecular weight
751.88 g/mol
Form
Lyophilized powder
CAS / ID
129954-34-3
0+
Published Studies
Anxiolytic & nootropic research
0
Amino Acids
Tuftsin-derived heptapeptide
Approved
Russia Regulatory Status
Approved in Russia for anxiety & neurosis
0
Research Areas
Anxiolytic Mechanisms · Memory & Learning · Cytokine & Immune Modulation & more
How It Works

How Selank works

The pathways Selank acts on — and what each one does. Signalling pathways studied in preclinical models · illustrative.

GABA-A Receptor Modulation

GABAergic

Research indicates Selank modulates GABAergic neurotransmission, including GABA-A receptor activity and expression of GABAergic system components. This mechanism is associated with the anxiolytic effects observed in preclinical animal models and early clinical studies, without the sedative or dependency concerns seen with classical benzodiazepines.

  • Modulates GABA-A receptor subunit expression
  • Anxiolytic effects without benzodiazepine-type sedation
  • No reported physical dependence in preclinical models
BDNF & Enkephalin Upregulation

Neurotrophin

Selank research demonstrates upregulation of brain-derived neurotrophic factor (BDNF) expression and enhancement of enkephalin metabolism. BDNF supports neuroplasticity and synaptic maintenance. Stabilization of enkephalin levels may contribute to the observed mood and cognitive effects in preclinical studies.

  • Increases BDNF expression in hippocampal regions
  • Stabilizes enkephalin via enkephalinase inhibition
  • Modulates serotonin and dopamine turnover
Tuftsin-Derived Immune Regulation

Immunomodulatory

Selank is derived from the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a proline-glycine-proline extension that enhances stability. Research demonstrates it modulates cytokine production including IL-6, IL-1β, and TNF-α expression, supporting its investigation as an anxiolytic with immunomodulatory properties.

  • Derived from tuftsin (natural immunomodulator)
  • Modulates pro-inflammatory cytokine expression
  • Influences interferon alpha/gamma signaling pathways
Uses & applications

What Selank is researched for

The main areas Selank is being studied for — and the study-reported figures behind them.

Neuropharmacology

Anxiolytic Mechanisms

Preclinical studies demonstrate anxiolytic effects in elevated plus maze and open field tests, attributed to GABAergic modulation. Selank shows anxiolytic activity comparable to diazepam without sedative side effects in rodent models.

Semenova et al. 2010

Cognitive Research

Memory & Learning

Research reports improved learning and memory consolidation in animal models of stress-induced cognitive impairment. BDNF upregulation and enkephalin stabilization are proposed as underlying mechanisms supporting synaptic plasticity.

Kozlovskaya et al. 2008

Immunology

Cytokine & Immune Modulation

Studies report Selank modulates expression of interleukin-6, TNF-α, and interferon signaling pathways, consistent with its tuftsin-derived immunomodulatory origin. Investigated as a model for peptide-based neuroimmunomodulation research.

Zozulya et al. 2012

Gene Expression

Transcriptomic Studies

Gene expression studies identify Selank-induced changes in transcription of genes related to serotonin, dopamine metabolism, and synaptic plasticity. Provides a molecular pharmacology research framework for peptide-based anxiolytics.

Inozemtseva et al. 2009

Study-reported magnitudes

Representative figures from published research. Bars fill as you scroll.

  • Anxiety Reduction (Preclinical Models)High
  • BDNF Expression IncreaseSignificant
  • Cognitive Performance (Memory Tasks)Improved
  • Cytokine Modulation (IL-6, TNF-α)Modulated

Figures are representative of published research findings and shown for reference.

Third-Party Verified

Independently tested. Verifiably pure.

Every batch of Selank is sent to an accredited independent laboratory before it ships. Here is what we screen for.

  • HPLC Purity AnalysisConfirms the peptide is ≥99% pure
  • Mass SpectrometryVerifies the exact molecular identity
  • Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
  • Endotoxins (LAL)Bacterial endotoxin levels — Pass
  • Sterility TestingNo microbial contamination — Pass
  • Net Peptide ContentActual peptide mass per vial verified
Compound Information

Full specification

Chemical NameThr-Lys-Pro-Arg-Pro-Gly-Pro (Selank)
SequenceH-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
Molecular Weight751.88 Da
Molecular FormulaC33H57N11O8
FormLyophilized powder
Purity≥99% (HPLC verified)
TestingThird-party HPLC, Mass Spec, Endotoxin
Storage-20°C for long-term stability
SolubilityWater or bacteriostatic water
COAIncluded with every order
FAQ

Common questions about Selank

Selank is a synthetic heptapeptide (7 amino acids) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is derived from the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), which is a natural fragment of IgG immunoglobulin. A Pro-Gly-Pro extension was added to increase the peptide's stability and half-life. Selank is approved in Russia as an anxiolytic drug for generalized anxiety disorder and neurasthenia.

Selank's anxiolytic effects are attributed to multiple mechanisms. Research indicates it modulates GABA-A receptor expression and GABAergic neurotransmission, similar to but distinct from benzodiazepines. It also upregulates BDNF (brain-derived neurotrophic factor), stabilizes enkephalin levels by inhibiting enkephalinase, and modulates serotonin and dopamine metabolism — creating a multi-target anxiolytic profile.

No. Selank is not approved by the FDA or the European Medicines Agency (EMA). It is approved in Russia under the brand name Selank for anxiety and neurasthenic conditions. Western clinical trial data is very limited, and most published research originates from Russian institutions. It is sold here for in vitro research use only.

Research suggests Selank modulates GABAergic activity through a different mechanism than benzodiazepines. Preclinical studies show anxiolytic effects without the sedation, motor impairment, or physical dependence observed with classical benzodiazepines. Selank appears to act as an anxioselective agent — reducing anxiety-related behaviors without producing sedation at effective doses in rodent models.

Selank is derived from tuftsin, a natural tetrapeptide with well-documented immunostimulatory properties. Research demonstrates Selank modulates cytokine production (IL-6, TNF-α, interferon signaling) and may act as a neuroimmune bridge. This dual neurological and immunological activity makes it of interest in neuroimmunomodulation research, investigating links between anxiety, stress, and immune function.

Lyophilized Selank should be stored at -20°C away from moisture and light. The Pro-Gly-Pro C-terminal extension improves Selank's resistance to proteolytic degradation compared to tuftsin, contributing to greater stability in biological research conditions.

Published Literature

Peer-reviewed literature

Independent published research indexed from PubMed and peer-reviewed journals — not Zorva Lab claims.

[1] PubMedThe Peptide Selank Inhibits Anxiety and Cognitive Deficits2010 · Semenova TP et al.View source →[2] PubMedThe Nootropic and Neuroprotective Properties of Selank in a Model of Neurodegeneration2008 · Kozlovskaya MM et al.View source →[3] PubMedImmunomodulating Activity of Selank and Its Analogs in Animal Models of Immune Disorders2012 · Zozulya AA et al.View source →[4] PubMedEffect of Selank on Gene Expression in the Hippocampus and Frontal Cortex2009 · Inozemtseva LS et al.View source →

For Research Use Only.

Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.

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