Cognitive Function Studies
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Semax is a seven amino acid peptide developed at a Russian research institute. Part of its sequence comes from ACTH, a hormone, and the rest is a short tail that keeps enzymes from breaking it down. Research in rodent models has measured BDNF, a protein involved in neuron growth, along with dopamine and serotonin activity. Despite the ACTH origin, it shows no stress hormone activity in testing.
Synthetic heptapeptide analog of ACTH(4-10)
The pathways Semax acts on — and what each one does. Signalling pathways studied in preclinical models · illustrative.
Semax increases brain-derived neurotrophic factor (BDNF) levels by up to 1.4-fold in specific brain regions, supporting neuronal survival, growth, and synaptic plasticity.
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
In ischemic stroke models, Semax demonstrates neuroprotective effects by reducing infarct volume, modulating inflammatory gene expression, and promoting neuronal survival under oxygen deprivation.
The main areas Semax is being studied for — and the study-reported figures behind them.
Enhances cognitive function, memory consolidation, and attention in animal models. Approved as a nootropic in Russia since 2011.
Ashmarin et al. 2006
Reduces ischemic brain damage and promotes neuronal survival in cerebral ischemia models. Used clinically in Russia for stroke recovery.
Gusev et al. 2010
Modulates expression of neurotrophins and their receptors, supporting neuronal plasticity and regeneration pathways.
Agapova et al. 2010
Reduces pro-inflammatory cytokines and modulates oxidative stress-related gene expression in hippocampal tissue.
Agapova et al. 2011
Representative figures from published research. Bars fill as you scroll.
Figures are representative of published research findings and shown for reference.
Every batch of Semax is sent to an accredited independent laboratory before it ships. Here is what we screen for.
| Strength | 10mg |
|---|---|
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | Synthetic analog of ACTH(4-10) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for up to 24 months |
| Solubility | Water-soluble |
| COA | Included with every order |
| Appearance | White to off-white powder |
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
Research has demonstrated that Semax may increase BDNF levels by up to 1.4-fold, modulate serotonergic and dopaminergic systems, have neuroprotective effects in ischemic stroke models, enhance cognitive function and memory in animal studies, and display anti-inflammatory properties.
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, increasing stability and resistance to enzymatic degradation. This results in a longer half-life and potentially enhanced bioavailability compared to standard Semax.
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). Protect from heat and direct light.
Independent published research indexed from PubMed and peer-reviewed journals — not Zorva Lab claims.
For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
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